The Effect of Fetal Liver-derived Cell Suspension Allotransplantation on Patients with Wolfram Syndrome: the First Year of Follow-up

The Effect of Fetal Liver-derived Cell Suspension Allotransplantation on Patients with Wolfram Syndrome: the First Year of Follow-up

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Background: Cell therapy has emerged as a promising curative intervention for several diseases including diabetes 8x10 Print and Wolfram Syndrome (WS).The current study aimed to assess the effectiveness of clinical application of fetal-liver derived stem cells for treatment of patients with WS.Methods: Six patients with WS aged 23-34 (mean: 29.

50, SD: 4.76) were recruited for the current phase 3 single-arm clinical trial.The participants underwent fetal liver-derived hematopoietic stem cell transplantation.

In order to evaluate the effectiveness of transplantation, glycemic control indexes IRON were measured at regular follow-up sessions.Results: One patient (out of six) experienced a 6 months insulin-free period with acceptable HbA1c levels.In another patient with history of recurrent hypoglycemic attacks, the frequency of bout of attacks remarkably decreased.

There was no significant change in other patients.Conclusion: Stem-cell therapy may represent a new method for treatment of patients with Wolfram Syndrome.Keywords: Stem Cell, Allotransplantation, Wolfram Syndrome, Diabetes.